View source for 6itf


==Icosahedral asymmetric unit (iASU) model of the less refined, coarse part of FHV eluted particle==
<SX load='6itf' size='340' side='right' viewer='molstar' caption='[[6itf]], [[Resolution|resolution]] 4.70&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6itf]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Flock_House_virus Flock House virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ITF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6ITF FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 4.7&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6itf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6itf OCA], [https://pdbe.org/6itf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6itf RCSB], [https://www.ebi.ac.uk/pdbsum/6itf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6itf ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/CAPSD_FHV CAPSD_FHV] Capsid protein alpha self-assembles to form an icosahedral procapsid with a T=3 symmetry, about 30 nm in diameter, and consisting of 60 capsid proteins trimers. In addition, 240 calcium ions are incorporated per capsid during assembly. The capsid encapsulates the two genomic RNAs. Capsid maturation occurs via autoproteolytic cleavage of capsid protein alpha generating capsid protein beta and the membrane-active peptide gamma.  Peptide gamma: membrane-permeabilizing peptide produced by virus maturation, thereby creating the infectious virion. After endocytosis into the host cell, peptide gamma is probably exposed in endosomes, where it permeabilizes the endosomal membrane, facilitating translocation of viral capsid or RNA into the cytoplasm (Probable).

==See Also==
*[[Flock house virus protein B2|Flock house virus protein B2]]
*[[Virus coat proteins 3D structures|Virus coat proteins 3D structures]]
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</SX>
[[Category: Flock House virus]]
[[Category: Large Structures]]
[[Category: Azad K]]
[[Category: Banerjee M]]