View source for 6iw5


==Crystal structure of YFV-China sE in prefusion state==
<StructureSection load='6iw5' size='340' side='right' caption='[[6iw5]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6iw5]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6IW5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6IW5 FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6iw5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6iw5 OCA], [http://pdbe.org/6iw5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6iw5 RCSB], [http://www.ebi.ac.uk/pdbsum/6iw5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6iw5 ProSAT]</span></td></tr>
</table>
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== Publication Abstract from PubMed ==
Yellow fever virus (YFV), a deadly human pathogen, is the prototype of the genus Flavivirus. Recently, YFV re-emerged in Africa and Brazil, leading to hundreds of deaths, with some cases imported to China. Prophylactic or therapeutic countermeasures are urgently needed. Previously, several human monoclonal antibodies against YFV were screened out by phage display. Here, we find that one of them, 5A, exhibits high neutralizing potency and good protection. Crystallographic analysis of the YFV envelope (E) protein in its pre- and post-fusion states shows conformations similar to those observed in other E proteins of flaviviruses. Furthermore, the structures of 5A in complex with the E protein in both states are resolved, revealing an invariant recognition site. Structural analysis and functional data suggest that 5A has high neutralization potency because it interferes with virus entry by preventing both virus attachment and fusion. These findings will be instrumental for immunogen or inhibitor design.

Double Lock of a Human Neutralizing and Protective Monoclonal Antibody Targeting the Yellow Fever Virus Envelope.,Lu X, Xiao H, Li S, Pang X, Song J, Liu S, Cheng H, Li Y, Wang X, Huang C, Guo T, Ter Meulen J, Daffis S, Yan J, Dai L, Rao Z, Klenk HD, Qi J, Shi Y, Gao GF Cell Rep. 2019 Jan 8;26(2):438-446.e5. doi: 10.1016/j.celrep.2018.12.065. PMID:30625326<ref>PMID:30625326</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Li, S H]]
[[Category: Lu, X S]]
[[Category: Pang, X F]]
[[Category: Xiao, H X]]
[[Category: Envelope protein]]
[[Category: Flavivirus]]
[[Category: Neutralizing monoclonal antibody]]
[[Category: Viral protein]]
[[Category: Yellow fever virus]]