View source for 6iyy


==Crystal structure of human WIPI3,loop deletion mutant==
<StructureSection load='6iyy' size='340' side='right'caption='[[6iyy]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6iyy]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6IYY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6IYY FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.796&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6iyy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6iyy OCA], [https://pdbe.org/6iyy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6iyy RCSB], [https://www.ebi.ac.uk/pdbsum/6iyy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6iyy ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/WIPI3_HUMAN WIPI3_HUMAN] The disease may be caused by mutations affecting the gene represented in this entry.
== Function ==
[https://www.uniprot.org/uniprot/WIPI3_HUMAN WIPI3_HUMAN] Component of the autophagy machinery that controls the major intracellular degradation process by which cytoplasmic materials are packaged into autophagosomes and delivered to lysosomes for degradation (PubMed:28561066). Binds phosphatidylinositol 3-phosphate (PtdIns3P) forming on membranes of the endoplasmic reticulum upon activation of the upstream ULK1 and PI3 kinases and is recruited at phagophore assembly sites where it regulates the elongation of nascent phagophores downstream of WIPI2 (PubMed:28561066). In the cellular response to starvation, may also function together with the TSC1-TSC2 complex and RB1CC1 in the inhibition of the mTORC1 signaling pathway (PubMed:28503735).<ref>PMID:28503735</ref> <ref>PMID:28561066</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Feng W]]
[[Category: Liang RB]]
[[Category: Ren JQ]]