View source for 6jcd


==G-quadruplex peripheral knot==
<StructureSection load='6jcd' size='340' side='right'caption='[[6jcd]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6jcd]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6JCD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6JCD FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6jcd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6jcd OCA], [https://pdbe.org/6jcd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6jcd RCSB], [https://www.ebi.ac.uk/pdbsum/6jcd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6jcd ProSAT]</span></td></tr>
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== Publication Abstract from PubMed ==
A knot-like G-quadruplex peripheral structure is formed by a 7-nt DNA sequence DL7 (TGTTGGT), in which six out of its seven nucleobases participate in compact base-pairing interactions. Here, the solution NMR structure of a 24-nt DNA oligonucleotide containing the DL7 sequence shows the interaction between a two-layer anti-parallel G-quadruplex core and the peripheral knot-like structure, including the construction of two sharp turns in the DNA backbone. The formation of this novel structural element highlights the intricate properties of single-stranded DNA folding in presence of G-quadruplex-forming motifs. We demonstrated the compatibility of the DL7 knot-like structure with various G-quadruplexes, which could have implications in drug design and DNA engineering.

An Unprecedented Knot-like G-Quadruplex Peripheral Motif.,Truong THA, Winnerdy FR, Phan AT Angew Chem Int Ed Engl. 2019 Jul 17. doi: 10.1002/anie.201907740. PMID:31317601<ref>PMID:31317601</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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== References ==
<references/>
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</StructureSection>
[[Category: Large Structures]]
[[Category: Synthetic construct]]
[[Category: Phan AT]]
[[Category: Truong THA]]
[[Category: Winnerdy FR]]