View source for 6jfk


==GDP bound Mitofusin2 (MFN2)==
<StructureSection load='6jfk' size='340' side='right'caption='[[6jfk]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6jfk]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6JFK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6JFK FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.997&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6jfk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6jfk OCA], [https://pdbe.org/6jfk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6jfk RCSB], [https://www.ebi.ac.uk/pdbsum/6jfk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6jfk ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/MFN2_HUMAN MFN2_HUMAN] Multiple symmetric lipomatosis;Autosomal dominant Charcot-Marie-Tooth disease type 2A2;Severe early-onset axonal neuropathy due to MFN2 deficiency;Hereditary motor and sensory neuropathy type 5;Hereditary motor and sensory neuropathy type 6. The disease is caused by mutations affecting the gene represented in this entry.  The disease is caused by mutations affecting the gene represented in this entry.  The disease is caused by mutations affecting the gene represented in this entry.
== Function ==
[https://www.uniprot.org/uniprot/MFN2_HUMAN MFN2_HUMAN] Mitochondrial outer membrane GTPase that mediates mitochondrial clustering and fusion (PubMed:11181170, PubMed:11950885, PubMed:28114303). Mitochondria are highly dynamic organelles, and their morphology is determined by the equilibrium between mitochondrial fusion and fission events (PubMed:28114303). Overexpression induces the formation of mitochondrial networks (PubMed:28114303). Membrane clustering requires GTPase activity and may involve a major rearrangement of the coiled coil domains (Probable). Plays a central role in mitochondrial metabolism and may be associated with obesity and/or apoptosis processes (By similarity). Plays an important role in the regulation of vascular smooth muscle cell proliferation (By similarity). Involved in the clearance of damaged mitochondria via selective autophagy (mitophagy) (PubMed:23620051). Is required for PRKN recruitment to dysfunctional mitochondria (PubMed:23620051). Involved in the control of unfolded protein response (UPR) upon ER stress including activation of apoptosis and autophagy during ER stress (By similarity). Acts as an upstream regulator of EIF2AK3 and suppresses EIF2AK3 activation under basal conditions (By similarity).[UniProtKB:Q80U63][UniProtKB:Q8R500]<ref>PMID:11181170</ref> <ref>PMID:11950885</ref> <ref>PMID:23620051</ref> <ref>PMID:26085578</ref> <ref>PMID:28114303</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Cao YL]]
[[Category: Chan DC]]
[[Category: Chen SD]]
[[Category: Chen XX]]
[[Category: Feng JX]]
[[Category: Gao S]]
[[Category: Hu JJ]]
[[Category: Kang SS]]
[[Category: Lan L]]
[[Category: Li YJ]]
[[Category: Luo L]]
[[Category: Meng SX]]
[[Category: Qi YB]]
[[Category: Yang JF]]
[[Category: Yu B]]
[[Category: Zhong YT]]