View source for 6jli


==Crystal structure of CTLD7 domain of human PLA2R==
<StructureSection load='6jli' size='340' side='right'caption='[[6jli]], [[Resolution|resolution]] 1.78&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6jli]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6JLI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6JLI FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.778&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6jli FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6jli OCA], [https://pdbe.org/6jli PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6jli RCSB], [https://www.ebi.ac.uk/pdbsum/6jli PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6jli ProSAT]</span></td></tr>
</table>
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== Publication Abstract from PubMed ==
M-type phospholipase A2 receptor (PLA2R) is a member of the mannose receptor family. Recent evidence shows that PLA2R is a major autoantigen causing idiopathic membranous nephropathy (IMN), which is an autoimmune disease and one of the most common causes for nephrotic syndrome in adults. The epitope mapping data suggest that the major epitopes of PLA2R locate at the CysR, CTLD1 and CTLD7 domains. However, due to the lack of the high-resolution structural information, it is unclear how the autoantibodies interact with PLA2R. Here we determine the crystal structure of the CTLD7 domain of PLA2R at 1.8A, showing that it adopts a typical CTLD fold, and the structural alignments also provide hints for the potential antibody binding regions. In addition, the high-resolution structural information of CTLD7 could be applied to identify the epitopes for autoantibodies, which would facilitate the therapeutic strategies against IMN.

Crystal structure of the CTLD7 domain of human M-type phospholipase A2 receptor.,Yu B, Hu Z, Kong D, Cheng C, He Y J Struct Biol. 2019 Jul 2. pii: S1047-8477(19)30136-4. doi:, 10.1016/j.jsb.2019.06.007. PMID:31271865<ref>PMID:31271865</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<div class="pdbe-citations 6jli" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Cheng C]]
[[Category: He Y]]
[[Category: Hu Z]]
[[Category: Kong D]]
[[Category: Yu B]]