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==Angiotensin II type 2 receptor with ligand==
<StructureSection load='6jod' size='340' side='right'caption='[[6jod]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6JOD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6JOD FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.2&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6jod FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6jod OCA], [https://pdbe.org/6jod PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6jod RCSB], [https://www.ebi.ac.uk/pdbsum/6jod PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6jod ProSAT]</span></td></tr>
</table>
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== Publication Abstract from PubMed ==
Angiotensin II (AngII) is a peptide hormone that plays a key role in regulating blood pressure, and its interactions with the G protein-coupled receptors, AngII type-1 receptor (AT1R) and AngII type-2 receptor (AT2R), are central to its mechanism of action. We solved the crystal structure of human AT2R bound to AngII and its specific antibody at 3.2-A resolution. AngII (full agonist) and [Sar(1), Ile(8)]-AngII (partial agonist) interact with AT2R in a similar fashion, except at the bottom of the AT2R ligand-binding pocket. In particular, the residues including Met128(3.36), which constitute the deep end of the cavity, play important roles in angiotensin receptor (ATR) activation upon AngII binding. These differences that occur upon endogenous ligand binding may contribute to a structural change in AT2R, leading to normalization of the non-canonical coordination of helix 8. Our results will inform the design of more effective ligands for ATRs.

The Crystal Structure of Angiotensin II Type 2 Receptor with Endogenous Peptide Hormone.,Asada H, Inoue A, Ngako Kadji FM, Hirata K, Shiimura Y, Im D, Shimamura T, Nomura N, Iwanari H, Hamakubo T, Kusano-Arai O, Hisano H, Uemura T, Suno C, Aoki J, Iwata S Structure. 2020 Apr 7;28(4):418-425.e4. doi: 10.1016/j.str.2019.12.003. Epub 2019, Dec 30. PMID:31899086<ref>PMID:31899086</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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== References ==
<references/>
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</StructureSection>
[[Category: Large Structures]]
[[Category: Asada H]]
[[Category: Hirata K]]
[[Category: Iwata S]]
[[Category: Shimamura T]]