View source for 6jqn


==Structure of PaaZ, a bifunctional enzyme in complex with NADP+ and OCoA==
<SX load='6jqn' size='340' side='right' viewer='molstar' caption='[[6jqn]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6jqn]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6JQN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6JQN FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.1&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CO8:OCTANOYL-COENZYME+A'>CO8</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6jqn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6jqn OCA], [https://pdbe.org/6jqn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6jqn RCSB], [https://www.ebi.ac.uk/pdbsum/6jqn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6jqn ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PAAZ_ECOLI PAAZ_ECOLI] Catalyzes the hydrolytic ring cleavage of 2-oxepin-2(3H)-ylideneacetyl-CoA (oxepin-CoA) via the open-chain aldehyde intermediate to yield 3-oxo-5,6-dehydrosuberyl-CoA. The enzyme consists of a C-terminal (R)-specific enoyl-CoA hydratase domain (formerly MaoC) that cleaves the ring and produces the highly reactive 3-oxo-5,6-dehydrosuberyl-CoA semialdehyde and an N-terminal NADP-dependent aldehyde dehydrogenase domain that oxidizes the aldehyde to 3-oxo-5,6-dehydrosuberyl-CoA. Can also use crotonyl-CoA as substrate.<ref>PMID:20660314</ref> <ref>PMID:21296885</ref> <ref>PMID:9748275</ref> 
== References ==
<references/>
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[[Category: Escherichia coli K-12]]
[[Category: Large Structures]]
[[Category: Cannone G]]
[[Category: Gakher L]]
[[Category: Katagihallimath N]]
[[Category: Sathyanarayanan N]]
[[Category: Sowdhamini R]]
[[Category: Vinothkumar KR]]