View source for 6jwe


==structure of RET G-quadruplex in complex with colchicine==
<StructureSection load='6jwe' size='340' side='right'caption='[[6jwe]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6jwe]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6JWE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6JWE FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LOC:N-[(7S)-1,2,3,10-TETRAMETHOXY-9-OXO-6,7-DIHYDRO-5H-BENZO[D]HEPTALEN-7-YL]ETHANAMIDE'>LOC</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6jwe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6jwe OCA], [https://pdbe.org/6jwe PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6jwe RCSB], [https://www.ebi.ac.uk/pdbsum/6jwe PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6jwe ProSAT]</span></td></tr>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
G-quadruplexes (G4s) are frequently formed in the promoter regions of oncogenes, considered as promising drug targets for anticancer therapy. Due to high structure similarity of G4s, discovering ligands selectively interacting with only one G4 is extremely difficult. Here, mainly by NMR, we report that colchicine selectively binds to oncogene RET G4-DNA.

Colchicine selective interaction with oncogene RET G-quadruplex revealed by NMR.,Wang F, Wang C, Liu Y, Lan W, Han H, Wang R, Huang S, Cao C Chem Commun (Camb). 2020 Feb 18;56(14):2099-2102. doi: 10.1039/d0cc00221f. Epub, 2020 Feb 6. PMID:32025680<ref>PMID:32025680</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 6jwe" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Cao C]]
[[Category: Lan WX]]
[[Category: Li YM]]
[[Category: Liu Y]]
[[Category: Wang C]]
[[Category: Wang F]]
[[Category: Wang RX]]