View source for 6k4v


==The solution structure of the smart chimeric peptide G6==
<StructureSection load='6k4v' size='340' side='right'caption='[[6k4v]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6k4v]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Arenicola_marina Arenicola marina]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6K4V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6K4V FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 10 models</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6k4v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6k4v OCA], [https://pdbe.org/6k4v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6k4v RCSB], [https://www.ebi.ac.uk/pdbsum/6k4v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6k4v ProSAT]</span></td></tr>
</table>
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== Publication Abstract from PubMed ==
Pathogenic Escherichia coli can cause fatal diarrheal diseases in both animals and humans. However, no antibiotics or antimicrobial peptides (AMPs) can adequately kill resistant bacteria and clear bacterial endotoxin, lipopolysaccharide (LPS) which leads to inflammation and sepsis. Here, the LPS-targeted smart chimeric peptides (SCPs)-A6 and G6 are generated by connecting LPS-targeting peptide-LBP14 and killing domain-N6 via different linkers. Rigid and flexible linkers retain the independent biological activities from each component. SCPs-A6 and G6 exert low toxicity and no bacterial resistance, and they more rapidly kill multiple-drug-resistant E. coli and more effectively neutralize LPS toxicity than N6 alone. The SCPs can enhance mouse survival more effectively than N6 or polymyxin B and alleviate lung injuries by blocking mitogen-activated protein kinase and nuclear factor kappa-B p65 activation. These findings uniquely show that SCPs-A6 and G6 may be promising dual-function candidates as improved antibacterial and anti-endotoxin agents to treat bacterial infection and sepsis.

Development of chimeric peptides to facilitate the neutralisation of lipopolysaccharides during bactericidal targeting of multidrug-resistant Escherichia coli.,Wang Z, Liu X, Da Teng, Mao R, Hao Y, Yang N, Wang X, Li Z, Wang X, Wang J Commun Biol. 2020 Jan 23;3(1):41. doi: 10.1038/s42003-020-0761-3. PMID:31974490<ref>PMID:31974490</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Arenicola marina]]
[[Category: Large Structures]]
[[Category: Liu XH]]
[[Category: Wang JH]]