View source for 6k86


==The closed state of RGLG1 mutant-E378A==
<StructureSection load='6k86' size='340' side='right'caption='[[6k86]], [[Resolution|resolution]] 1.59&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6k86]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6K86 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6K86 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.593&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6k86 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6k86 OCA], [https://pdbe.org/6k86 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6k86 RCSB], [https://www.ebi.ac.uk/pdbsum/6k86 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6k86 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/RGLG1_ARATH RGLG1_ARATH] E3 ubiquitin-protein ligase that mediates the formation of 'Lys-63'-linked ubiquitin chains. Regulates apical dominance by acting on the auxin transport proteins abundance (PubMed:17586653). Together with RGLG5, mediates the ubiquitination and subsequent proteasomal degradation of the target protein PP2CA. Functions as positive regulator of abscisic acid (ABA) signaling through ABA-dependent degradation of PP2CA, a major inhibitor of ABA signaling (PubMed:27577789). Acts as a negative regulator of drought stress response (PubMed:22095047).<ref>PMID:17586653</ref> <ref>PMID:22095047</ref> <ref>PMID:27577789</ref> 

==See Also==
*[[Ubiquitin protein ligase 3D structures|Ubiquitin protein ligase 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Arabidopsis thaliana]]
[[Category: Large Structures]]
[[Category: Wang Q]]
[[Category: Wu Y]]