View source for 6kmf


==FimA type V pilus from P.gingivalis==
<StructureSection load='6kmf' size='340' side='right'caption='[[6kmf]], [[Resolution|resolution]] 3.60&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6kmf]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Porphyromonas_gingivalis_ATCC_33277 Porphyromonas gingivalis ATCC 33277]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6KMF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6KMF FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.6&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6kmf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6kmf OCA], [https://pdbe.org/6kmf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6kmf RCSB], [https://www.ebi.ac.uk/pdbsum/6kmf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6kmf ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/FIMA1_PORG3 FIMA1_PORG3] Structural subunit of the major fimbriae. These long, filamentous pili are attached to the cell surface; they mediate biofilm formation, adhesion onto host cells and onto other bacteria that are part of the oral microbiome (PubMed:9786913, PubMed:12593606, PubMed:15165251, PubMed:17675496, PubMed:17526848, PubMed:20530728, PubMed:27062925). They play an important role in the invasion of periodontal tissues (PubMed:12593606). Fimbriae and their constituents are major virulence factors. FimA proteins from different strains have highly divergent sequences, and this has been used for classification (PubMed:23809984). The sequence-based classification correlates with pathogenicity (PubMed:17675496).<ref>PMID:12593606</ref> <ref>PMID:15165251</ref> <ref>PMID:17526848</ref> <ref>PMID:17675496</ref> <ref>PMID:20530728</ref> <ref>PMID:23809984</ref> <ref>PMID:27062925</ref> <ref>PMID:9786913</ref> 

==See Also==
*[[Pilin 3D structures|Pilin 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Porphyromonas gingivalis ATCC 33277]]
[[Category: Imada K]]
[[Category: Matsunami H]]
[[Category: Matthews M]]
[[Category: Nakayama K]]
[[Category: Shibata S]]
[[Category: Shoji M]]
[[Category: Wolf M]]