View source for 6ko9


==Crystal structure of the Gefitinib Intermediate 1 bound RamR determined with XtaLAB Synergy==
<StructureSection load='6ko9' size='340' side='right'caption='[[6ko9]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6ko9]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_Typhimurium_str._14028S Salmonella enterica subsp. enterica serovar Typhimurium str. 14028S]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6KO9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6KO9 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=XZ1:4-[(3-chloranyl-4-fluoranyl-phenyl)amino]-7-methoxy-quinazolin-6-ol'>XZ1</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ko9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ko9 OCA], [https://pdbe.org/6ko9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ko9 RCSB], [https://www.ebi.ac.uk/pdbsum/6ko9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ko9 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/Q8ZR43_SALTY Q8ZR43_SALTY] 
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The structure determination of organic compounds is desirable for the development of medicines, aroma chemicals, and agricultural chemicals. However, the crystallization of organic compounds is often troublesome, because crystallization requires a relatively large quantity of high purity compounds and crystallization trials often need to be performed repetitively using different conditions. Some proteins are known to be able to bind to various organic compounds. The multidrug-resistance regulator protein RamR is one such protein. We have developed a structure determination method for organic compounds using RamR. RamR bound to organic compounds, including one compound that was not a known ligand for RamR, and the structures of the complexes were successfully determined. Because the RamR crystal is hydrophilic, this method may be useful for compounds that cannot be handled by the crystalline sponge method.

Development of a structure determination method using a multidrug-resistance regulator protein as a framework.,Matsumoto T, Nakashima R, Yamano A, Nishino K Biochem Biophys Res Commun. 2019 Oct 15;518(2):402-408. doi:, 10.1016/j.bbrc.2019.08.070. Epub 2019 Aug 17. PMID:31431261<ref>PMID:31431261</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 6ko9" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Salmonella enterica subsp. enterica serovar Typhimurium str. 14028S]]
[[Category: Matsumoto T]]
[[Category: Nakashima R]]
[[Category: Nishino K]]
[[Category: Yamano A]]