View source for 6kz8


==Crystal structure of plant Phospholipase D alpha complex with phosphatidic acid==
<StructureSection load='6kz8' size='340' side='right'caption='[[6kz8]], [[Resolution|resolution]] 2.29&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6kz8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6KZ8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6KZ8 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.291&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=PA8:1,2-DIOCTANOYL-SN-GLYCERO-3-PHOSPHATE'>PA8</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6kz8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6kz8 OCA], [https://pdbe.org/6kz8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6kz8 RCSB], [https://www.ebi.ac.uk/pdbsum/6kz8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6kz8 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PLDA1_ARATH PLDA1_ARATH] Hydrolyzes glycerol-phospholipids at the terminal phosphodiesteric bond to generate phosphatidic acids (PA). Plays an important role in various cellular processes, including phytohormone action and response to stress, characterized by acidification of the cell (PubMed:9437863). Involved in wound induction of jasmonic acid (PubMed:11090221). May be involved in membrane lipid remodeling (PubMed:11239826). Probably involved in freezing tolerance by modulating the cold-responsive genes and accumulation of osmolytes (PubMed:16949955). Can use phosphatidylcholine (PC), phosphatidylethanolamine (PE) and phosphatidylglycerol (PG) as substrates, both in presence or in absence of PIP2 (PubMed:9578608). Its main substrate is phosphatidylcholine (PubMed:11239826). Stimulates the intrinsic GTPase activity of GPA1 upon binding (PubMed:14594812). Mediates the abscisic acid effects on stomata through interaction with GPA1 and the production of phosphatidic acid that bind to ABI1 (PubMed:17261695, PubMed:17565616). Involved in seed aging and deterioration (PubMed:17565616). Involved in microtubule stabilization and salt tolerance (PubMed:23150630). Involved in abscisic acid-induced stomatal closure (PubMed:22392280).<ref>PMID:10441386</ref> <ref>PMID:11090221</ref> <ref>PMID:11239826</ref> <ref>PMID:14594812</ref> <ref>PMID:16614222</ref> <ref>PMID:16949955</ref> <ref>PMID:17261695</ref> <ref>PMID:17565616</ref> <ref>PMID:22392280</ref> <ref>PMID:23150630</ref> <ref>PMID:9437863</ref> <ref>PMID:9578608</ref> 

==See Also==
*[[Phospholipase D 3D structures|Phospholipase D 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Arabidopsis thaliana]]
[[Category: Large Structures]]
[[Category: Li JX]]
[[Category: Yu F]]
[[Category: Zhang P]]