View source for 6kzd


==Crystal structure of TRKc in complex with 3-((6-(4-aminophenyl)imidazo[1,2-a]pyrazin-3-yl)ethynyl)- N-(3-isopropyl-5-((4-methylpiperazin-1-yl)methyl)phenyl)-2- methylbenzamide==
<StructureSection load='6kzd' size='340' side='right'caption='[[6kzd]], [[Resolution|resolution]] 1.71&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6kzd]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6KZD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6KZD FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.708&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DZ6:3-[2-[6-(4-aminophenyl)imidazo[1,2-a]pyrazin-3-yl]ethynyl]-2-methyl-~{N}-[3-(4-methylpiperazin-1-yl)-5-propan-2-yl-phenyl]benzamide'>DZ6</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6kzd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6kzd OCA], [https://pdbe.org/6kzd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6kzd RCSB], [https://www.ebi.ac.uk/pdbsum/6kzd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6kzd ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/NTRK3_HUMAN NTRK3_HUMAN] Receptor for neurotrophin-3 (NT-3). This is a tyrosine-protein kinase receptor. Known substrates for the trk receptors are SHC1, PI-3 kinase, and PLCG1. The different isoforms do not have identical signaling properties.

==See Also==
*[[TrkB tyrosine kinase receptor|TrkB tyrosine kinase receptor]]
*[[Tyrosine kinase receptor 3D structures|Tyrosine kinase receptor 3D structures]]
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Wang Y]]
[[Category: Zhang ZM]]