View source for 6l92


==A basket type G-quadruplex in WNT DNA promoter==
<StructureSection load='6l92' size='340' side='right'caption='[[6l92]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6l92]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6L92 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6L92 FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6l92 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6l92 OCA], [https://pdbe.org/6l92 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6l92 RCSB], [https://www.ebi.ac.uk/pdbsum/6l92 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6l92 ProSAT]</span></td></tr>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Time-resolved imino proton nuclear magnetic resonance spectra of the WT22m sequence d(GGGCCACCGGGCAGTGGGCGGG), derived from the WNT1 promoter region, revealed an intermediate G-quadruplex G4(I) structure during K+-induced conformational transition from an initial hairpin structure to the final G4(II) structure. Moreover, a single-base C-to-T mutation at either position C4 or C7 of WT22m could lock the intermediate G4(I) structure without further conformational change to the final G4(II) structure. Surprisingly, we found that the intermediate G4(I) structure is an atypical G4 structure, which differs from a typical hybrid G4 structure of the final G4(II) structure. Further studies of modified cytosine analogues associated with epigenetic regulation indicated that slight modification on a cytosine could modulate G4 structure. A simplified four-state transition model was introduced to describe such conformational transition and disclose the possible mechanism for G4 structural selection caused by cytosine modification.

Cytosine epigenetic modification modulates the formation of an unprecedented G4 structure in the WNT1 promoter.,Wang ZF, Li MH, Chu IT, Winnerdy FR, Phan AT, Chang TC Nucleic Acids Res. 2020 Jan 8. pii: 5698138. doi: 10.1093/nar/gkz1207. PMID:31912153<ref>PMID:31912153</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 6l92" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Chang TC]]
[[Category: Chu IT]]
[[Category: Li MH]]
[[Category: Phan AT]]
[[Category: Wang ZF]]
[[Category: Winnerdy FR]]