View source for 6lfs


==Poa1p H23A mutant in complex with ADP-ribose==
<StructureSection load='6lfs' size='340' side='right'caption='[[6lfs]], [[Resolution|resolution]] 1.87&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6lfs]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6LFS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6LFS FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.87&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=APR:ADENOSINE-5-DIPHOSPHORIBOSE'>APR</scene>, <scene name='pdbligand=CXS:3-CYCLOHEXYL-1-PROPYLSULFONIC+ACID'>CXS</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6lfs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6lfs OCA], [https://pdbe.org/6lfs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6lfs RCSB], [https://www.ebi.ac.uk/pdbsum/6lfs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6lfs ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/POA1_YEAST POA1_YEAST] Highly specific phosphatase involved in the metabolism of ADP-ribose 1''-phosphate (Appr1p) which is produced as a consequence of tRNA splicing. Removes ADP-ribose from glutamate residues in proteins bearing a single ADP-ribose moiety. Inactive towards proteins bearing poly-ADP-ribose.<ref>PMID:10550052</ref> <ref>PMID:15684411</ref> <ref>PMID:23474712</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Saccharomyces cerevisiae S288C]]
[[Category: Chiu YC]]
[[Category: Hsu CH]]