View source for 6lo8


==Cryo-EM structure of the TIM22 complex from yeast==
<StructureSection load='6lo8' size='340' side='right'caption='[[6lo8]], [[Resolution|resolution]] 3.83&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6lo8]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6LO8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6LO8 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.83&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6lo8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6lo8 OCA], [https://pdbe.org/6lo8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6lo8 RCSB], [https://www.ebi.ac.uk/pdbsum/6lo8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6lo8 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/TIM22_YEAST TIM22_YEAST] Essential core component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins, such as mitochondrial carrier family members, into the mitochondrial inner membrane. In the TIM22 complex, it constitutes the voltage-activated and signal-gated channel. Forms a twin-pore translocase that uses the membrane potential as external driving force in 2 voltage-dependent steps. Mediates the insertion of precursor proteins in a 3 step process. After the precursor is tethered to the translocase without losing energy from the Delta(psi), 2 energy-requiring steps are needed. First, Delta(psi) acts on the precursor protein and promotes its docking in the translocase complex. Then, Delta(psi) and an internal signal peptide together induce rapid gating transitions in one pore and closing of the other pore and drive membrane insertion to completion.<ref>PMID:11864609</ref> <ref>PMID:12637749</ref> <ref>PMID:8955274</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Saccharomyces cerevisiae S288C]]
[[Category: Li L]]
[[Category: Wu X]]
[[Category: Zhang Y]]
[[Category: Zhou X]]