View source for 6lry


==Crystal structure of human endothelin ETB receptor in complex with sarafotoxin S6b==
<StructureSection load='6lry' size='340' side='right'caption='[[6lry]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6lry]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Atractaspis_engaddensis Atractaspis engaddensis], [https://en.wikipedia.org/wiki/Enterobacteria_phage_RB59 Enterobacteria phage RB59] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6LRY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6LRY FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6lry FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6lry OCA], [https://pdbe.org/6lry PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6lry RCSB], [https://www.ebi.ac.uk/pdbsum/6lry PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6lry ProSAT]</span></td></tr>
</table>
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== Publication Abstract from PubMed ==
Sarafotoxins (SRTXs) are endothelin-like peptides extracted from snake venom. SRTXs stimulate the endothelin ETA and ETB receptors and enhance vasoconstriction, followed by left ventricular dysfunction and bronchoconstriction. SRTXs include four major isopeptides, S6a-d, with different subtype selectivities. Here, we report the crystal structure of the human ETB receptor in complex with the non-selective sarafotoxin S6b at 3.0 A resolution. This structure reveals the similarities and differences between the binding modes of the endothelins and S6b. Moreover, molecular dynamics simulations based on the S6b-bound receptor provides structural insight into the subtype selectivity of the sarafotoxins. Our study clarifies the recognition mechanism of the endothelin-like peptide families.

Crystal structure of human endothelin ETB receptor in complex with sarafotoxin S6b.,Izume T, Miyauchi H, Shihoya W, Nureki O Biochem Biophys Res Commun. 2020 Jan 28. pii: S0006-291X(20)30021-8. doi:, 10.1016/j.bbrc.2019.12.091. PMID:32001000<ref>PMID:32001000</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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== References ==
<references/>
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</StructureSection>
[[Category: Atractaspis engaddensis]]
[[Category: Enterobacteria phage RB59]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Izume T]]
[[Category: Miyauchi H]]
[[Category: Nureki O]]
[[Category: Shihoya W]]