View source for 6lvt


==Solution structure of holo acyl carrier protein from Thermotoga maritima==
<StructureSection load='6lvt' size='340' side='right'caption='[[6lvt]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6lvt]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermotoga_maritima_MSB8 Thermotoga maritima MSB8]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6LVT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6LVT FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6lvt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6lvt OCA], [https://pdbe.org/6lvt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6lvt RCSB], [https://www.ebi.ac.uk/pdbsum/6lvt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6lvt ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/ACP_THEMA ACP_THEMA] Carrier of the growing fatty acid chain in fatty acid biosynthesis.[HAMAP-Rule:MF_01217]
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Thermotoga maritima, a deep-branching hyperthermophilic bacterium, expresses an extraordinarily stable Thermotoga maritima acyl carrier protein (Tm-ACP) that functions as a carrier in the fatty acid synthesis system at near-boiling aqueous environments. Here, to understand the hyperthermal adaptation of Tm-ACP, we investigated the structure and dynamics of Tm-ACP by nuclear magnetic resonance (NMR) spectroscopy. The melting temperature of Tm-ACP (101.4 degrees C) far exceeds that of other ACPs, owing to extensive ionic interactions and tight hydrophobic packing. The D59 residue, which replaces Pro/Ser of other ACPs, mediates ionic clustering between helices III and IV. This creates a wide pocket entrance to facilitate the accommodation of long acyl chains required for hyperthermal adaptation of the T. maritima cell membrane. Tm-ACP is revealed to be the first ACP that harbor an amide proton hyperprotected against hydrogen/deuterium exchange for I15. The hydrophobic interactions mediated by I15 appear to be the key driving forces of the global folding process of Tm-ACP. Our findings provide insights into the structural basis of the hyperthermal adaptation of ACP, which might have allowed T. maritima to survive in hot ancient oceans.

Structural Characterization of an ACP from Thermotoga maritima: Insights into Hyperthermal Adaptation.,Lee Y, Jang A, Jeong MC, Park N, Park J, Lee WC, Cheong C, Kim Y Int J Mol Sci. 2020 Apr 9;21(7). pii: ijms21072600. doi: 10.3390/ijms21072600. PMID:32283632<ref>PMID:32283632</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 6lvt" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Thermotoga maritima MSB8]]
[[Category: Kim Y]]
[[Category: Lee Y]]