View source for 6lwt


==Crystal structure of Staphylococcal Superantigen-Like protein 10==
<StructureSection load='6lwt' size='340' side='right'caption='[[6lwt]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6lwt]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6LWT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6LWT FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6lwt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6lwt OCA], [https://pdbe.org/6lwt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6lwt RCSB], [https://www.ebi.ac.uk/pdbsum/6lwt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6lwt ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/SSL10_STAA8 SSL10_STAA8] Plays a role in the inhibition of host complement activation via the classical pathway by interacting with the Fc region of human IgG and thereby interfering with the IgG/C1q interaction (PubMed:19913916). Inhibits also the penultimate step of plasma clotting by interacting with prothrombin/F2 and coagulation factor X/F12. Does not affect the protease activity of thrombin but interferes with the conversion of prothrombin to thrombin (PubMed:23754290, PubMed:28193526). Interacts with human receptor CXCR4 and specifically inhibits CXCL12-induced calcium mobilization and cell migration (PubMed:19308288).<ref>PMID:19308288</ref> <ref>PMID:19913916</ref> <ref>PMID:23754290</ref> <ref>PMID:28193526</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Staphylococcus aureus]]
[[Category: Chengliang W]]
[[Category: Nan J]]
[[Category: Tianrong H]]