View source for 6m49


==cryo-EM structure of Scap/Insig complex in the present of 25-hydroxyl cholesterol.==
<StructureSection load='6m49' size='340' side='right'caption='[[6m49]], [[Resolution|resolution]] 3.70&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6m49]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6M49 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6M49 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.7&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HC3:25-HYDROXYCHOLESTEROL'>HC3</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6m49 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6m49 OCA], [https://pdbe.org/6m49 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6m49 RCSB], [https://www.ebi.ac.uk/pdbsum/6m49 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6m49 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/INSI2_HUMAN INSI2_HUMAN] Mediates feedback control of cholesterol synthesis by controlling SCAP and HMGCR. Functions by blocking the processing of sterol regulatory element-binding proteins (SREBPs). Capable of retaining the SCAP-SREBF2 complex in the ER thus preventing it from escorting SREBPs to the Golgi. Seems to regulate the ubiquitin-mediated proteasomal degradation of HMGCR.<ref>PMID:12242332</ref> <ref>PMID:16606821</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Brown AJ]]
[[Category: Cao P]]
[[Category: Coates HW]]
[[Category: Du X]]
[[Category: Gao S]]
[[Category: Gong X]]
[[Category: Lei J]]
[[Category: Li Y]]
[[Category: Liu X]]
[[Category: Qian H]]
[[Category: Song W]]
[[Category: Sui J]]
[[Category: Yan C]]
[[Category: Yan N]]
[[Category: Yan R]]
[[Category: Yang H]]
[[Category: Zhao X]]
[[Category: Zhou Q]]