View source for 6mdo


==The D1 and D2 domain rings of NSF engaging the SNAP-25 N-terminus within the 20S supercomplex (focused refinement on D1/D2 rings, class 1)==
<SX load='6mdo' size='340' side='right' viewer='molstar' caption='[[6mdo]], [[Resolution|resolution]] 3.90&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6mdo]] is a 7 chain structure with sequence from [https://en.wikipedia.org/wiki/Cricetulus_griseus Cricetulus griseus] and [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MDO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6MDO FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.9&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6mdo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mdo OCA], [https://pdbe.org/6mdo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6mdo RCSB], [https://www.ebi.ac.uk/pdbsum/6mdo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6mdo ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/NSF_CRIGR NSF_CRIGR] Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seem to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin. Interaction with AMPAR subunit GRIA2 leads to influence GRIA2 membrane cycling.

==See Also==
*[[ATPase 3D structures|ATPase 3D structures]]
*[[Synaptosomal-associated protein|Synaptosomal-associated protein]]
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[[Category: Cricetulus griseus]]
[[Category: Large Structures]]
[[Category: Rattus norvegicus]]
[[Category: Brunger AT]]
[[Category: White KI]]
[[Category: Zhao M]]