View source for 6mf8


==TCR alpha transmembrane domain==
<StructureSection load='6mf8' size='340' side='right'caption='[[6mf8]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6mf8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MF8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6MF8 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6mf8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mf8 OCA], [https://pdbe.org/6mf8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6mf8 RCSB], [https://www.ebi.ac.uk/pdbsum/6mf8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6mf8 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/TRAC_MOUSE TRAC_MOUSE] Constant region of T cell receptor (TR) alpha chain. Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens. Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn, ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation. The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity.[UniProtKB:P01848]

==See Also==
*[[T-cell receptor 3D structures|T-cell receptor 3D structures]]
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</StructureSection>
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Brazin KN]]
[[Category: Reinherz EL]]