View source for 6mfb


==Crystal structure of 3-hydroxykynurenine transaminase from Aedes aegypti==
<StructureSection load='6mfb' size='340' side='right'caption='[[6mfb]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6mfb]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Aedes_aegypti Aedes aegypti]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MFB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6MFB FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6mfb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mfb OCA], [https://pdbe.org/6mfb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6mfb RCSB], [https://www.ebi.ac.uk/pdbsum/6mfb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6mfb ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/HKT_AEDAE HKT_AEDAE] Catalyzes the pyridoxal 5'-phosphate-dependent transamination of both 3-hydroxykynurenine and L-kynurenine to xanthurenic acid and kynurenic acid, respectively, preferentially using the alpha-ketoacid pyruvate, glyoxylate or oxaloacetate as the amino group acceptor (PubMed:11880382, PubMed:12220660). The affinity and catalytic efficiency for 3-hydroxykynurenine is higher than for L-kynurenine (PubMed:12220660). Involved in the detoxification of cytotoxic metabolite 3-hydroxykynurenine generated by the hydroxylation of L-kynurenine, an intermediate in the tryptophan catabolism pathway (PubMed:11880382, PubMed:12220660). Also catalyzes, although with a lesser efficiency, the transamination of alanine with glyoxylate as an amino group acceptor (PubMed:11880382). May play a role in the detoxification of glyoxylate, a toxic plant metabolite from the diet (Probable).<ref>PMID:11880382</ref> <ref>PMID:12220660</ref> <ref>PMID:11880382</ref> <ref>PMID:12220660</ref> 

==See Also==
*[[Aminotransferase 3D structures|Aminotransferase 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Aedes aegypti]]
[[Category: Large Structures]]
[[Category: Guido RVC]]
[[Category: Maciel LG]]
[[Category: Oliveira AA]]
[[Category: Romao TP]]
[[Category: Silva Filha MHNL]]
[[Category: Soares TA]]
[[Category: Dos Anjos JV]]