View source for 6mha


==dHP1 Chromodomain Y24W variant bound to histone H3 peptide containing trimethyllysine==
<StructureSection load='6mha' size='340' side='right'caption='[[6mha]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6mha]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MHA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6MHA FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.497&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=M3L:N-TRIMETHYLLYSINE'>M3L</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6mha FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mha OCA], [https://pdbe.org/6mha PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6mha RCSB], [https://www.ebi.ac.uk/pdbsum/6mha PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6mha ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/HP1_DROME HP1_DROME] Structural component of heterochromatin, involved in gene repression and the modification of position-effect-variegation. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression.
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</StructureSection>
[[Category: Drosophila melanogaster]]
[[Category: Large Structures]]
[[Category: Albanese KI]]
[[Category: Brustad EM]]
[[Category: Krone MW]]
[[Category: Waters ML]]