View source for 6mhw


==Structure of human TRPV3 in the presence of 2-APB in C2 symmetry (1)==
<SX load='6mhw' size='340' side='right' viewer='molstar' caption='[[6mhw]], [[Resolution|resolution]] 4.00&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6mhw]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MHW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6MHW FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 4&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6mhw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mhw OCA], [https://pdbe.org/6mhw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6mhw RCSB], [https://www.ebi.ac.uk/pdbsum/6mhw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6mhw ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/TRPV3_HUMAN TRPV3_HUMAN] Mutilating palmoplantar keratoderma with periorificial keratotic plaques. The disease is caused by mutations affecting the gene represented in this entry.  The disease is caused by mutations affecting the gene represented in this entry.
== Function ==
[https://www.uniprot.org/uniprot/TRPV3_HUMAN TRPV3_HUMAN] Putative receptor-activated non-selective calcium permeant cation channel. It is activated by innocuous (warm) temperatures and shows an increased response at noxious temperatures greater than 39 degrees Celsius. Activation exhibits an outward rectification. May associate with TRPV1 and may modulate its activity. Is a negative regulator of hair growth and cycling: TRPV3-coupled signaling suppresses keratinocyte proliferation in hair follicles and induces apoptosis and premature hair follicle regression (catagen).<ref>PMID:12077604</ref> <ref>PMID:12077606</ref> <ref>PMID:21593771</ref> 

==See Also==
*[[Ion channels 3D structures|Ion channels 3D structures]]
== References ==
<references/>
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Borschel WF]]
[[Category: Herzik MA]]
[[Category: Hirschi M]]
[[Category: Lander GC]]
[[Category: Lee SY]]
[[Category: Song A]]
[[Category: Wu M]]
[[Category: Zubcevic L]]