View source for 6mlu


==Cryo-EM structure of lipid droplet formation protein Seipin/BSCL2==
<SX load='6mlu' size='340' side='right' viewer='molstar' caption='[[6mlu]], [[Resolution|resolution]] 4.00&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6mlu]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MLU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6MLU FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 4&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6mlu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mlu OCA], [https://pdbe.org/6mlu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6mlu RCSB], [https://www.ebi.ac.uk/pdbsum/6mlu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6mlu ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/BSCL2_DROME BSCL2_DROME] Is a regulator of lipid catabolism essential for adipocyte differentiation. May also be involved in the central regulation of energy homeostasis (By similarity). Necessary for correct lipid storage and lipid droplets maintenance; plays a tissue-autonomous role in controlling lipid storage in adipocytes and in preventing ectopic lipid droplet formation in non-adipose tissues. May participate in phosphatidic acid metabolism and subsequently down-regulate lipogenesis.[UniProtKB:Q9Z2E9]<ref>PMID:21533227</ref> 
== References ==
<references/>
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[[Category: Drosophila melanogaster]]
[[Category: Large Structures]]
[[Category: Arlt H]]
[[Category: Farese VR]]
[[Category: Liao M]]
[[Category: Sui X]]
[[Category: Walther CT]]