View source for 6mzv


==Cryo-EM structure of the HO BMC shell: BMC-TD focused structure, widened inner ring==
<SX load='6mzv' size='340' side='right' viewer='molstar' caption='[[6mzv]], [[Resolution|resolution]] 3.40&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6mzv]] is a 42 chain structure with sequence from [https://en.wikipedia.org/wiki/Haliangium_ochraceum_DSM_14365 Haliangium ochraceum DSM 14365]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MZV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6MZV FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.4&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6mzv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mzv OCA], [https://pdbe.org/6mzv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6mzv RCSB], [https://www.ebi.ac.uk/pdbsum/6mzv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6mzv ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/BMCT2_HALO1 BMCT2_HALO1] A minor component of the bacterial microcompartment (BMC) shell. Expression of 5 proteins in E.coli (BMC-H (Hoch_5815), BMC-P (Hoch_5814), and 3 BMC-T (Hoch_5812, Hoch_5816, Hoch_3341)) forms 40 nm artificial BMCs with a molecular mass of 6.5 MDa. One of 2 stacked pseudohexamers in the BMC. There are 20 BMC-T pseudohexamers per BMC, composed of mixed BMC-T1, BMC-T2 and BMC-T3. The shell facets are 20-30 Angstroms thick, with 1 of the stacked BMC-T trimers protruding to the exterior (PubMed:28642439, PubMed:30833088). The stacked trimers may serve as conduits to allow chemical flux across the protein shell, gated by Arg-70 which contacts Glu-69 in an adjacent subunit; they are flexible enough to play a role in accommodating variations in shell assembly (Probable).<ref>PMID:28642439</ref> <ref>PMID:30833088</ref> <ref>PMID:30833088</ref> 
== References ==
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[[Category: Haliangium ochraceum DSM 14365]]
[[Category: Large Structures]]
[[Category: Greber BJ]]
[[Category: Kerfeld CA]]
[[Category: Sutter M]]