View source for 6ndu


==Structure of human PACRG-MEIG1 complex==
<StructureSection load='6ndu' size='340' side='right'caption='[[6ndu]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6ndu]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6NDU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6NDU FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ndu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ndu OCA], [https://pdbe.org/6ndu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ndu RCSB], [https://www.ebi.ac.uk/pdbsum/6ndu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ndu ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PACRG_HUMAN PACRG_HUMAN] Suppresses cell death induced by accumulation of unfolded Pael receptor (Pael-R, a substrate of Parkin). Facilitates the formation of inclusions consisting of Pael-R, molecular chaperones, protein degradation molecules and itself when proteasome is inhibited. May play an important role in the formation of Lewy bodies and protection of dopaminergic neurons against Parkinson disease.<ref>PMID:14532270</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Croteau N]]
[[Category: Khan N]]
[[Category: Pelletier D]]
[[Category: Trempe JF]]
[[Category: Veyron S]]