View source for 6nko


==Crystal structure of ForH==
<StructureSection load='6nko' size='340' side='right'caption='[[6nko]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6nko]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_kaniharaensis Streptomyces kaniharaensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6NKO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6NKO FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.403&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6nko FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6nko OCA], [https://pdbe.org/6nko PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6nko RCSB], [https://www.ebi.ac.uk/pdbsum/6nko PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6nko ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/A0A4V8H038_9ACTN A0A4V8H038_9ACTN] 
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Formycin A is a potent purine nucleoside antibiotic with a C-glycosidic linkage between the ribosyl moiety and the pyrazolopyrimidine base. Herein, a cosmid is identified from the Streptomyces kaniharaensis genome library that contains the for gene cluster responsible for the biosynthesis of formycin. Subsequent gene deletion experiments and in vitro characterization of the forBCH gene products established their catalytic functions in formycin biosynthesis. Results also demonstrated that PurH from de novo purine biosynthesis plays a key role in pyrazolopyrimidine formation during biosynthesis of formycin A. The participation of PurH in both pathways represents a good example of how primary and secondary metabolism are interlinked.

Identification of the Formycin A Biosynthetic Gene Cluster from Streptomyces kaniharaensis Illustrates the Interplay between Biological Pyrazolopyrimidine Formation and de Novo Purine Biosynthesis.,Wang SA, Ko Y, Zeng J, Geng Y, Ren D, Ogasawara Y, Irani S, Zhang Y, Liu HW J Am Chem Soc. 2019 Apr 8. doi: 10.1021/jacs.9b00241. PMID:30942582<ref>PMID:30942582</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 6nko" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Streptomyces kaniharaensis]]
[[Category: Irani S]]
[[Category: Zhang Y]]
[[Category: Zheng J]]