View source for 6nlo


==Human ABCC6 NBD1 H812A in Apo state==
<StructureSection load='6nlo' size='340' side='right'caption='[[6nlo]], [[Resolution|resolution]] 2.85&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6nlo]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6NLO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6NLO FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8502197&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6nlo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6nlo OCA], [https://pdbe.org/6nlo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6nlo RCSB], [https://www.ebi.ac.uk/pdbsum/6nlo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6nlo ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/MRP6_HUMAN MRP6_HUMAN] Generalized arterial calcification of infancy;Pseudoxanthoma elasticum. The disease is caused by mutations affecting the gene represented in this entry. Homozygous or compound heterozygous ABCC6 mutations have been found in the overwhelming majority of cases. Individuals carrying heterozygous mutations express limited manifestations of the pseudoxanthoma elasticum phenotype.  The disease is caused by mutations affecting the gene represented in this entry.
== Function ==
[https://www.uniprot.org/uniprot/MRP6_HUMAN MRP6_HUMAN] Isoform 1: May participate directly in the active transport of drugs into subcellular organelles or influence drug distribution indirectly. Transports glutathione conjugates as leukotriene-c4 (LTC4) and N-ethylmaleimide S-glutathione (NEM-GS).<ref>PMID:11880368</ref>   Isoform 2: Inhibits TNF-alpha-mediated apoptosis through blocking one or more caspases.<ref>PMID:23912081</ref> 
== References ==
<references/>
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Thibodeau PH]]
[[Category: Zheng A]]