View source for 6nre


==Monomeric Lipocalin Can F 6==
<StructureSection load='6nre' size='340' side='right'caption='[[6nre]], [[Resolution|resolution]] 2.06&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6nre]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Canis_lupus_familiaris Canis lupus familiaris]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6NRE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6NRE FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.06&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6nre FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6nre OCA], [https://pdbe.org/6nre PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6nre RCSB], [https://www.ebi.ac.uk/pdbsum/6nre PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6nre ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/LI601_CANLF LI601_CANLF] 
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Lipocalins represent the most important protein family of the mammalian respiratory allergens. Four of the seven named dog allergens are lipocalins: Can f 1, Can f 2, Can f 4, and Can f 6. We present the structure of Can f 6 along with data on the biophysical and biological activity of this protein in comparison with other animal lipocalins. The Can f 6 structure displays the classic lipocalin calyx-shaped ligand binding cavity within a central beta-barrel similar to other lipocalins. Despite low sequence identity between the different dog lipocalin proteins, there is a high degree of structural similarity. On the other hand, Can f 6 has a similar primary sequence to cat, horse, mouse lipocalins as well as a structure that may underlie their cross reactivity. Interestingly, the entrance to the ligand binding pocket is capped by a His instead of the usually seen Tyr that may help select its natural ligand binding partner. Our highly pure recombinant Can f 6 is able to bind to human IgE (hIgE) demonstrating biological antigenicity.

Structural characteristics of lipocalin allergens: Crystal structure of the immunogenic dog allergen Can f 6.,Clayton GM, White J, Lee S, Kappler JW, Chan SK PLoS One. 2019 Sep 16;14(9):e0213052. doi: 10.1371/journal.pone.0213052. , eCollection 2019. PMID:31525203<ref>PMID:31525203</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 6nre" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Canis lupus familiaris]]
[[Category: Large Structures]]
[[Category: Chan S]]
[[Category: Clayton G M]]
[[Category: Kappler J W]]