View source for 6o62


==Crystal structure of Sec4p, a Rab family GTPase from Candida albicans==
<StructureSection load='6o62' size='340' side='right'caption='[[6o62]], [[Resolution|resolution]] 1.88&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6o62]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Candida_albicans_SC5314 Candida albicans SC5314]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6O62 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6O62 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.88&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6o62 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6o62 OCA], [https://pdbe.org/6o62 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6o62 RCSB], [https://www.ebi.ac.uk/pdbsum/6o62 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6o62 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/SEC4_CANAL SEC4_CANAL] Involved in exocytosis. Maybe by regulating the binding and fusion of secretory vesicles with the cell surface. The GTP-bound form of SEC4 may interact with an effector, thereby stimulating its activity and leading to exocytotic fusion. SEC4 may be an upstream activator of the 19.5S SEC8/SEC15 particle. SEC4 probably interacts directly with SEC8; it could serve as the attachment site for the SEC8/SEC15 particle (By similarity).

==See Also==
*[[GTP-binding protein 3D structures|GTP-binding protein 3D structures]]
__TOC__
</StructureSection>
[[Category: Candida albicans SC5314]]
[[Category: Large Structures]]
[[Category: Di Leo R]]
[[Category: Savchenko A]]
[[Category: Skarina T]]
[[Category: Stogios PJ]]