View source for 6odb


==Crystal structure of HDAC8 in complex with compound 3==
<StructureSection load='6odb' size='340' side='right'caption='[[6odb]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6odb]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ODB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6ODB FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=M8G:N-{2-[(1E)-3-(hydroxyamino)-3-oxoprop-1-en-1-yl]phenyl}-2-phenoxybenzamide'>M8G</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6odb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6odb OCA], [https://pdbe.org/6odb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6odb RCSB], [https://www.ebi.ac.uk/pdbsum/6odb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6odb ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/HDAC8_HUMAN HDAC8_HUMAN] Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. May play a role in smooth muscle cell contractility.<ref>PMID:10748112</ref> <ref>PMID:10926844</ref> <ref>PMID:10922473</ref> <ref>PMID:14701748</ref> 

==See Also==
*[[Histone deacetylase 3D structures|Histone deacetylase 3D structures]]
== References ==
<references/>
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Bair K]]
[[Category: Barczak N]]
[[Category: Caravella J]]
[[Category: Conti C]]
[[Category: Garcia-Dancey R]]
[[Category: Han B]]
[[Category: Hardy C]]
[[Category: Lahdenranta J]]
[[Category: Lancia Jr D]]
[[Category: Leng C]]
[[Category: Li P]]
[[Category: Liu C]]
[[Category: Martin M]]
[[Category: Ng PY]]
[[Category: Pardo E]]
[[Category: Rudnitskaya A]]
[[Category: Saldahna A]]
[[Category: Tan T]]
[[Category: Thomason JJ]]
[[Category: Toms AV]]
[[Category: Yao L]]
[[Category: Zablocki M-M]]
[[Category: Zhang C]]
[[Category: Zheng X]]