View source for 6on4


==Crystal structure of the GntR-type sialoregulator NanR from Escherichia coli, in complex with sialic acid==
<StructureSection load='6on4' size='340' side='right'caption='[[6on4]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6on4]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ON4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6ON4 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=P4K:polyethylene+glycol'>P4K</scene>, <scene name='pdbligand=SLB:5-N-ACETYL-BETA-D-NEURAMINIC+ACID'>SLB</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6on4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6on4 OCA], [https://pdbe.org/6on4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6on4 RCSB], [https://www.ebi.ac.uk/pdbsum/6on4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6on4 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/NANR_ECOLI NANR_ECOLI] Transcriptional repressor that controls expression of the genes required for the catabolism of sialic acids (PubMed:9864311, PubMed:12897000, PubMed:23935044). Represses expression of the nanATEK-yhcH, nanCMS and yjhBC operons. Acts by binding directly to the Nan box, a region of approximately 30 bp covering the promoter region (PubMed:23935044).<ref>PMID:12897000</ref> <ref>PMID:23935044</ref> <ref>PMID:9864311</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Escherichia coli K-12]]
[[Category: Large Structures]]
[[Category: Dobson RCJ]]
[[Category: Horne CR]]
[[Category: North RA]]
[[Category: Panjikar S]]