View source for 6oov


==Crystal structure of HMCES SRAP domain in complex with palindromic 3' overhang DNA==
<StructureSection load='6oov' size='340' side='right'caption='[[6oov]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6oov]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6OOV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6OOV FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6oov FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6oov OCA], [https://pdbe.org/6oov PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6oov RCSB], [https://www.ebi.ac.uk/pdbsum/6oov PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6oov ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/HMCES_HUMAN HMCES_HUMAN] Specifically binds 5-hydroxymethylcytosine (5hmC)-containing DNA in stem cells, suggesting that it acts as a specific reader of 5hmC in stem cells (By similarity). May act as a peptidase; experimental evidences are however required to confirm this prediction (PubMed:23945014).<ref>PMID:23945014</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Synthetic construct]]
[[Category: Arrowsmith CH]]
[[Category: Bountra C]]
[[Category: Edwards AM]]
[[Category: Halabelian L]]
[[Category: Li Y]]
[[Category: Zeng H]]