View source for 6pbc


==Structural basis for the activation of PLC-gamma isozymes by phosphorylation and cancer-associated mutations==
<StructureSection load='6pbc' size='340' side='right'caption='[[6pbc]], [[Resolution|resolution]] 2.46&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6pbc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6PBC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6PBC FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.46&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6pbc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6pbc OCA], [https://pdbe.org/6pbc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6pbc RCSB], [https://www.ebi.ac.uk/pdbsum/6pbc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6pbc ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/G3V845_RAT G3V845_RAT] Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.[PIRNR:PIRNR000952]

==See Also==
*[[Phospholipase C|Phospholipase C]]
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Rattus norvegicus]]
[[Category: Hajicek N]]
[[Category: Sondek J]]