View source for 6pbf


==ZINC9155420-bound TRPV5 in nanodiscs==
<SX load='6pbf' size='340' side='right' viewer='molstar' caption='[[6pbf]], [[Resolution|resolution]] 4.20&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6pbf]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6PBF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6PBF FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 4.2&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=O6V:(1S)-1-(4-oxo-5-phenyl-3,4-dihydrothieno[2,3-d]pyrimidin-2-yl)ethyl+[(2S)-3-oxo-3,4-dihydro-2H-1,4-benzothiazin-2-yl]acetate'>O6V</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6pbf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6pbf OCA], [https://pdbe.org/6pbf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6pbf RCSB], [https://www.ebi.ac.uk/pdbsum/6pbf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6pbf ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/TRPV5_RABIT TRPV5_RABIT] Constitutively active calcium selective cation channel thought to be involved in Ca(2+) reabsorption in kidney and intestine (PubMed:12574114). Required for normal Ca(2+) reabsorption in the kidney distal convoluted tubules (By similarity). The channel is activated by low internal calcium level and the current exhibits an inward rectification (By similarity). A Ca(2+)-dependent feedback regulation includes fast channel inactivation and slow current decay (By similarity). Heteromeric assembly with TRPV6 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating (PubMed:12574114).[UniProtKB:P69744][UniProtKB:Q9NQA5]<ref>PMID:10085067</ref> <ref>PMID:11035011</ref> <ref>PMID:12574114</ref> 

==See Also==
*[[Ion channels 3D structures|Ion channels 3D structures]]
== References ==
<references/>
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[[Category: Large Structures]]
[[Category: Oryctolagus cuniculus]]
[[Category: Filizola M]]
[[Category: Fluck EC]]
[[Category: Hughes TET]]
[[Category: Kapoor A]]
[[Category: Moiseenkova-Bell VY]]
[[Category: Rohacs T]]
[[Category: Rosario JSD]]
[[Category: Yazici AT]]