View source for 6por


==Antimicrobial lasso peptide ubonodin==
<StructureSection load='6por' size='340' side='right'caption='[[6por]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6por]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Burkholderia_ubonensis Burkholderia ubonensis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6POR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6POR FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 20 models</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6por FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6por OCA], [https://pdbe.org/6por PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6por RCSB], [https://www.ebi.ac.uk/pdbsum/6por PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6por ProSAT]</span></td></tr>
</table>
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== Publication Abstract from PubMed ==
We report the heterologous expression, structure, and antimicrobial activity of a lasso peptide, ubonodin, encoded in the genome of Burkholderia ubonensis . The topology of ubonodin is unprecedented amongst lasso peptides with 18 of its 28 amino acids found in the mechanically-bonded loop segment. Ubonodin inhibits RNA polymerase in vitro and has potent antimicrobial activity against several pathogenic members of the Burkholderia genus, most notably B. cepacia and B. multivorans , causative agents of lung infections in cystic fibrosis patients.

Discovery of ubonodin, an antimicrobial lasso peptide active against members of the Burkholderia cepacia complex.,Cheung-Lee WL, Parry M, Zong C, Jaramillo Cartagena A, Darst S, Connell N, Russo R, Link AJ Chembiochem. 2019 Nov 25. doi: 10.1002/cbic.201900707. PMID:31765515<ref>PMID:31765515</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 6por" style="background-color:#fffaf0;"></div>
== References ==
<references/>
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</StructureSection>
[[Category: Burkholderia ubonensis]]
[[Category: Large Structures]]
[[Category: Cheung-Lee WL]]
[[Category: Link AJ]]