View source for 6ptl


==Structure of the self-association domain of the chromatin looping factor LDB1==
<StructureSection load='6ptl' size='340' side='right'caption='[[6ptl]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6ptl]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6PTL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6PTL FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ptl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ptl OCA], [https://pdbe.org/6ptl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ptl RCSB], [https://www.ebi.ac.uk/pdbsum/6ptl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ptl ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/LDB1_MOUSE LDB1_MOUSE] Binds to the LIM domain of a wide variety of LIM domain-containing transcription factors. May regulate the transcriptional activity of LIM-containing proteins by determining specific partner interactions. May play a role in the development of motor neurons. Acts synergistically with LHX1/LIM1 in axis formation and activation of gene expression. Acts with LMO2 in the regulation of red blood cell development, maintaining erythroid precursors in an immature state.<ref>PMID:8918878</ref> <ref>PMID:8876198</ref> <ref>PMID:9192866</ref> <ref>PMID:9391090</ref> <ref>PMID:16815859</ref> <ref>PMID:9315627</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Guss JM]]
[[Category: Macindoe I]]
[[Category: Mackay JP]]
[[Category: Matthews JM]]
[[Category: Silva A]]