View source for 6ptz


==Crystal structure of pigeon Cryptochrome 4 mutant Y319D in complex with flavin adenine dinucleotide==
<StructureSection load='6ptz' size='340' side='right'caption='[[6ptz]], [[Resolution|resolution]] 1.79&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6ptz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Columba_livia Columba livia]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6PTZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6PTZ FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.793&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ptz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ptz OCA], [https://pdbe.org/6ptz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ptz RCSB], [https://www.ebi.ac.uk/pdbsum/6ptz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ptz ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/A0A2I0LZR8_COLLI A0A2I0LZR8_COLLI] 
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Computational and biochemical studies implicate the blue-light sensor cryptochrome (CRY) as an endogenous light-dependent magnetosensor enabling migratory birds to navigate using the Earth's magnetic field. Validation of such a mechanism has been hampered by the absence of structures of vertebrate CRYs that have functional photochemistry. Here we present crystal structures of Columba livia (pigeon) CRY4 that reveal evolutionarily conserved modifications to a sequence of Trp residues (Trp-triad) required for CRY photoreduction. In ClCRY4, the Trp-triad chain is extended to include a fourth Trp (W369) and a Tyr (Y319) residue at the protein surface that imparts an unusually high quantum yield of photoreduction. These results are consistent with observations of night migratory behavior in animals at low light levels and could have implications for photochemical pathways allowing magnetosensing.

Chemical and structural analysis of a photoactive vertebrate cryptochrome from pigeon.,Zoltowski BD, Chelliah Y, Wickramaratne A, Jarocha L, Karki N, Xu W, Mouritsen H, Hore PJ, Hibbs RE, Green CB, Takahashi JS Proc Natl Acad Sci U S A. 2019 Sep 24;116(39):19449-19457. doi:, 10.1073/pnas.1907875116. Epub 2019 Sep 4. PMID:31484780<ref>PMID:31484780</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 6ptz" style="background-color:#fffaf0;"></div>

==See Also==
*[[Cryptochrome 3D structures|Cryptochrome 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Columba livia]]
[[Category: Large Structures]]
[[Category: Chelliah Y]]
[[Category: Green CB]]
[[Category: Hibbs RE]]
[[Category: Hore PJ]]
[[Category: Jarocha L]]
[[Category: Karki N]]
[[Category: Mouritsen H]]
[[Category: Takahashi JS]]
[[Category: Wickramaratne AC]]
[[Category: Zoltowski BD]]