View source for 6pvl


==Cryo-EM structure of mouse TRPV3 in closed state at 42 degrees Celsius==
<SX load='6pvl' size='340' side='right' viewer='molstar' caption='[[6pvl]], [[Resolution|resolution]] 4.40&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6pvl]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6PVL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6PVL FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 4.4&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6pvl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6pvl OCA], [https://pdbe.org/6pvl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6pvl RCSB], [https://www.ebi.ac.uk/pdbsum/6pvl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6pvl ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/TRPV3_MOUSE TRPV3_MOUSE] Putative receptor-activated non-selective calcium permeant cation channel. It is activated by innocuous (warm) temperatures and shows an increased response at noxious temperatures greater than 39 degrees Celsius. Activation exhibits an outward rectification. May associate with TRPV1 and may modulate its activity. Is a negative regulator of hair growth and cycling: TRPV3-coupled signaling suppresses keratinocyte proliferation in hair follicles and induces apoptosis and premature hair follicle regression (catagen) (By similarity).

==See Also==
*[[Ion channels 3D structures|Ion channels 3D structures]]
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[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: McGoldrick LL]]
[[Category: Singh AK]]
[[Category: Sobolevsky AI]]