View source for 6pvm


==Cryo-EM structure of mouse TRPV3 in putative sensitized state at 42 degrees Celsius==
<SX load='6pvm' size='340' side='right' viewer='molstar' caption='[[6pvm]], [[Resolution|resolution]] 4.50&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6pvm]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6PVM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6PVM FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 4.5&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6pvm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6pvm OCA], [https://pdbe.org/6pvm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6pvm RCSB], [https://www.ebi.ac.uk/pdbsum/6pvm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6pvm ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/TRPV3_MOUSE TRPV3_MOUSE] Putative receptor-activated non-selective calcium permeant cation channel. It is activated by innocuous (warm) temperatures and shows an increased response at noxious temperatures greater than 39 degrees Celsius. Activation exhibits an outward rectification. May associate with TRPV1 and may modulate its activity. Is a negative regulator of hair growth and cycling: TRPV3-coupled signaling suppresses keratinocyte proliferation in hair follicles and induces apoptosis and premature hair follicle regression (catagen) (By similarity).

==See Also==
*[[Ion channels 3D structures|Ion channels 3D structures]]
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[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: McGoldrick LL]]
[[Category: Singh AK]]
[[Category: Sobolevsky AI]]