View source for 6q69


==Crystal structure of porcine ACBD3 GOLD domain in complex with 3A protein of enterovirus-G1==
<StructureSection load='6q69' size='340' side='right'caption='[[6q69]], [[Resolution|resolution]] 2.75&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6q69]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Porcine_enterovirus_9 Porcine enterovirus 9] and [https://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6Q69 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6Q69 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.747&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6q69 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6q69 OCA], [https://pdbe.org/6q69 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6q69 RCSB], [https://www.ebi.ac.uk/pdbsum/6q69 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6q69 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/Q6DUB6_PIG Q6DUB6_PIG] 
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Picornaviruses infect a wide range of mammals including livestock such as cattle and swine. As with other picornavirus genera such as Aphthovirus, there is emerging evidence of a significant economic impact of livestock infections caused by members of the genera Enterovirus and Kobuvirus. While the human-infecting enteroviruses and kobuviruses have been intensively studied during the past decades in great detail, research on livestock-infecting viruses has been mostly limited to the genomic characterization of the viral strains identified worldwide. Here, we extend our previous studies of the structure and function of the complexes composed of the non-structural 3A proteins of human-infecting enteroviruses and kobuviruses and the host ACBD3 protein and present a structural and functional characterization of the complexes of the following livestock-infecting picornaviruses: bovine enteroviruses EV-E and EV-F, porcine enterovirus EV-G, and porcine kobuvirus AiV-C. We present a series of crystal structures of these complexes and demonstrate the role of these complexes in facilitation of viral replication.

Structural basis for hijacking of the host ACBD3 protein by bovine and porcine enteroviruses and kobuviruses.,Smola M, Horova V, Boura E, Klima M Arch Virol. 2019 Dec 16. pii: 10.1007/s00705-019-04490-9. doi:, 10.1007/s00705-019-04490-9. PMID:31845156<ref>PMID:31845156</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 6q69" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Porcine enterovirus 9]]
[[Category: Sus scrofa]]
[[Category: Boura E]]
[[Category: Klima M]]
[[Category: Smola M]]