View source for 6qd5


==X-ray Structure of the Human Urea Channel SLC14A1/UT1==
<StructureSection load='6qd5' size='340' side='right'caption='[[6qd5]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6qd5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6QD5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6QD5 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.398&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BOG:B-OCTYLGLUCOSIDE'>BOG</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=Y01:CHOLESTEROL+HEMISUCCINATE'>Y01</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6qd5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6qd5 OCA], [https://pdbe.org/6qd5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6qd5 RCSB], [https://www.ebi.ac.uk/pdbsum/6qd5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6qd5 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/UT1_HUMAN UT1_HUMAN] Urea channel that facilitates transmembrane urea transport down a concentration gradient. A constriction of the transmembrane channel functions as selectivity filter through which urea is expected to pass in dehydrated form. The rate of urea conduction is increased by hypotonic stress. Plays an important role in the kidney medulla collecting ducts, where it allows rapid equilibration between the lumen of the collecting ducts and the interstitium, and thereby prevents water loss driven by the high concentration of urea in the urine. Facilitates urea transport across erythrocyte membranes. May also play a role in transmembrane water transport, possibly by indirect means.

==See Also==
*[[Urea transporter|Urea transporter]]
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Arrowsmith CH]]
[[Category: Borkowska O]]
[[Category: Bountra C]]
[[Category: Burgess-Brown NA]]
[[Category: Chalk R]]
[[Category: Chi G]]
[[Category: Dietz L]]
[[Category: Durr KL]]
[[Category: Edwards AM]]
[[Category: Ellis K]]
[[Category: Kliszcak M]]
[[Category: Man H]]
[[Category: Mckinley G]]
[[Category: Moreau C]]
[[Category: Mukhopadhyay SMM]]
[[Category: Pike ACW]]
[[Category: Scacioc A]]
[[Category: Shrestha L]]
[[Category: Snee M]]
[[Category: Von Delft F]]