View source for 6qgk


==Structure of human Bcl-2 in complex with THIQ-phenyl pyrazole compound==
<StructureSection load='6qgk' size='340' side='right'caption='[[6qgk]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6qgk]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6QGK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6QGK FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=J1Q:1-[2-[[(3~{S})-3-(aminomethyl)-3,4-dihydro-1~{H}-isoquinolin-2-yl]carbonyl]phenyl]-~{N},~{N}-dibutyl-5-methyl-pyrazole-3-carboxamide'>J1Q</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[6qg8|6qg8]], [[6qgg|6qgg]], [[6qgh|6qgh]], [[6qgj|6qgj]]</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6qgk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6qgk OCA], [http://pdbe.org/6qgk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6qgk RCSB], [http://www.ebi.ac.uk/pdbsum/6qgk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6qgk ProSAT]</span></td></tr>
</table>
== Disease ==
[[http://www.uniprot.org/uniprot/BCL2_HUMAN BCL2_HUMAN]] Note=A chromosomal aberration involving BCL2 has been found in chronic lymphatic leukemia. Translocation t(14;18)(q32;q21) with immunoglobulin gene regions. BCL2 mutations found in non-Hodgkin lymphomas carrying the chromosomal translocation could be attributed to the Ig somatic hypermutation mechanism resulting in nucleotide transitions. 
== Function ==
[[http://www.uniprot.org/uniprot/BCL2_HUMAN BCL2_HUMAN]] Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1).<ref>PMID:18570871</ref>  
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Casara, P]]
[[Category: Chen, I]]
[[Category: Davidson, J]]
[[Category: Davis, B]]
[[Category: Diguarher, T Le]]
[[Category: Dokurno, P]]
[[Category: Geneste, O]]
[[Category: Graham, C J]]
[[Category: Harris, R]]
[[Category: Hickman, J]]
[[Category: Hubbard, R E]]
[[Category: Jordan, A M]]
[[Category: Kotschy, A]]
[[Category: Matassova, N]]
[[Category: Murray, J]]
[[Category: Pedder, C]]
[[Category: Ray, S]]
[[Category: Roughley, S]]
[[Category: Smith, J]]
[[Category: Stark, J]]
[[Category: Walmsley, C]]
[[Category: Wang, Y]]
[[Category: Whitehead, N]]
[[Category: Williamson, D S]]
[[Category: Apoptosis]]
[[Category: Bcl2]]
[[Category: Drug design]]
[[Category: Small molecule inhibitor]]