View source for 6rb9


==The pore structure of Clostridium perfringens epsilon toxin==
<SX load='6rb9' size='340' side='right' viewer='molstar' caption='[[6rb9]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6rb9]] is a 7 chain structure with sequence from [https://en.wikipedia.org/wiki/Clostridium_perfringens_B Clostridium perfringens B]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RB9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6RB9 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.2&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6rb9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6rb9 OCA], [https://pdbe.org/6rb9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6rb9 RCSB], [https://www.ebi.ac.uk/pdbsum/6rb9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6rb9 ProSAT]</span></td></tr>
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== Function ==
[https://www.uniprot.org/uniprot/ETXB_CLOPF ETXB_CLOPF] 
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== Publication Abstract from PubMed ==
Epsilon toxin (Etx), a potent pore forming toxin (PFT) produced by Clostridium perfringens, is responsible for the pathogenesis of enterotoxaemia of ruminants and has been suggested to play a role in multiple sclerosis in humans. Etx is a member of the aerolysin family of beta-PFTs (abeta-PFTs). While the Etx soluble monomer structure was solved in 2004, Etx pore structure has remained elusive due to the difficulty of isolating the pore complex. Here we show the cryo-electron microscopy structure of Etx pore assembled on the membrane of susceptible cells. The pore structure explains important mutant phenotypes and suggests that the double beta-barrel, a common feature of the abeta-PFTs, may be an important structural element in driving efficient pore formation. These insights provide the framework for the development of novel therapeutics to prevent human and animal infections, and are relevant for nano-biotechnology applications.

The pore structure of Clostridium perfringens epsilon toxin.,Savva CG, Clark AR, Naylor CE, Popoff MR, Moss DS, Basak AK, Titball RW, Bokori-Brown M Nat Commun. 2019 Jun 14;10(1):2641. doi: 10.1038/s41467-019-10645-8. PMID:31201325<ref>PMID:31201325</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<div class="pdbe-citations 6rb9" style="background-color:#fffaf0;"></div>
== References ==
<references/>
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[[Category: Clostridium perfringens B]]
[[Category: Large Structures]]
[[Category: Basak AK]]
[[Category: Bokori-Brown M]]
[[Category: Clark AR]]
[[Category: Moss DS]]
[[Category: Naylor CE]]
[[Category: Popoff MR]]
[[Category: Savva CG]]
[[Category: Titball RW]]