View source for 6rlo


==Crystal structure of AT1412dm Fab fragment in complex with CD9 large extracellular loop==
<StructureSection load='6rlo' size='340' side='right'caption='[[6rlo]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6rlo]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RLO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6RLO FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6rlo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6rlo OCA], [https://pdbe.org/6rlo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6rlo RCSB], [https://www.ebi.ac.uk/pdbsum/6rlo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6rlo ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/CD9_HUMAN CD9_HUMAN] Integral membrane protein associated with integrins, which regulates different processes, such as sperm-egg fusion, platelet activation and aggregation, and cell adhesion (PubMed:8478605, PubMed:14575715, PubMed:18541721). Present at the cell surface of oocytes and plays a key role in sperm-egg fusion, possibly by organizing multiprotein complexes and the morphology of the membrane required for the fusion (By similarity). In myoblasts, associates with CD81 and PTGFRN and inhibits myotube fusion during muscle regeneration (By similarity). In macrophages, associates with CD81 and beta-1 and beta-2 integrins, and prevents macrophage fusion into multinucleated giant cells specialized in ingesting complement-opsonized large particles (PubMed:12796480). Also prevents the fusion between mononuclear cell progenitors into osteoclasts in charge of bone resorption (By similarity). Acts as a receptor for PSG17 (By similarity). Involved in platelet activation and aggregation (PubMed:18541721). Regulates paranodal junction formation (By similarity). Involved in cell adhesion, cell motility and tumor metastasis (PubMed:8478605, PubMed:7511626).[UniProtKB:P40240]<ref>PMID:12796480</ref> <ref>PMID:14575715</ref> <ref>PMID:18541721</ref> <ref>PMID:7511626</ref> <ref>PMID:8478605</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Gros P]]
[[Category: Neviani V]]
[[Category: Pearce NM]]
[[Category: Pos W]]
[[Category: Schotte R]]
[[Category: Spits H]]