View source for 6ry3


==Structure of the WUS homeodomain==
<StructureSection load='6ry3' size='340' side='right'caption='[[6ry3]], [[Resolution|resolution]] 1.37&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6ry3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RY3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6RY3 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.374&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ry3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ry3 OCA], [https://pdbe.org/6ry3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ry3 RCSB], [https://www.ebi.ac.uk/pdbsum/6ry3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ry3 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/WUS_ARATH WUS_ARATH] Transcription factor that plays a central role during early embryogenesis, oogenesis and flowering, probably by regulating expression of specific genes. Required to specify stem cell identity in meristems, such as shoot apical meristem (SAM). May induce shoot stem cells activity in order to maintain the stem cell identity. Involved in the developmental root meristem. In shoot apices, it is sufficient to induce the expression of CLV3, a putative ligand of the CLV signaling pathway. Also required to sustain organogenesis in the floral meristem by contributing to the expression of its own repressor, the AGAMOUS (AG) gene at the end of flower development. Binds directly to the 5'-TTAAT[GC][GC]-3' DNA sequence in the regulatory sequence of AG and activates its expression directly. Regulates one important step in ovule development to induce integument formation from the underlying chalazal domain. Participates in the promotion of vegetative to embryonic transition. Required to repress LEC1 expression.<ref>PMID:10761929</ref> <ref>PMID:11440721</ref> <ref>PMID:11440722</ref> <ref>PMID:12000682</ref> <ref>PMID:12000795</ref> <ref>PMID:12068101</ref> <ref>PMID:12070094</ref> <ref>PMID:12070095</ref> <ref>PMID:15004006</ref> <ref>PMID:9865698</ref> 
== References ==
<references/>
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</StructureSection>
[[Category: Arabidopsis thaliana]]
[[Category: Large Structures]]
[[Category: Sinning I]]
[[Category: Sloan JJ]]
[[Category: Wild K]]